Ste. Genevieve is home to the best collection French Colonial architectural treasures including three of the five existing poteaux en terre (posts in the ground) buildings remaining in the United States as well as many poteaux sur solle (posts on sill) structures. In addition, the town includes early 19th century American and German vernacular buildings that show the influence of migrations into the area after the Louisiana Purchase.

As part of its mission, the Foundation for Restoration of Ste. Genevieve actively supports the preservation and restoration of these important buildings.

The Ste. Genevieve National Historic Landmark district was established in and recognizes the historic and cultural importance of the town’s buildings.